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Second messengers and luminescence in the brittlestar Amphipholis squamata Y Dewael; N De Breameker ; F Baguet; Jerome Mallefet*; UCL - Lab. animal physiology, Carnoy build., 5 place Croix du Sud, B-1348 Louvain-la-Neuve, Belgium      *(mallefet@bani.ucl.ac.be) We investigated the effects of cyclic nucleotides (cGMP, cAMP) and the phosphoinositide IP3 on the luminescence of the ophiuroid Amphipholis squamata. The cGMP analog, dibutyryl-cGMP and the guanylate cyclase activator, sodium nitroprusside had no effect on the luminescence. The cAMP analog, dibutyryl-cAMP and adenylate cyclase activator, forskolin triggered luminescence. Moreover, the adenylate cyclase inhibitor, MDL-12330A, reduced significantly acetylcholine-induced luminescence. The phospholipase C inhibitor, U-73122 reduced also significantly acetylcholine-induced luminescence. The results suggest that acetylcholine-induced luminescence is mediated by both cAMP and IP3 pathways but not by cGMP. The effects of calcium-free ASW confirmed this hypothesis. A hypothetical scheme of the transduction mechanisms involved in the intracellular control of luminescence is presented. [Talk: mallefet.jerome.65331]

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