Abstract Preview Page

This is an automatically generated preview of the abstract you selected.

Microwave-assisted synthesis of chemiluminescent acridinium salts M Adamczyk; YY Chen; JR Fino; Phillip G. Mattingly* Abbott Laboratories, 100 Abbott Park Rd, D09NM, BLDG AP20, Abbott Park, IL, 60064-6016, USA      *(phillip.g.mattingly@abbott.com) Sulfopropylated acridinium salts have proven to be more hydrophilic than their N10-methylated analogues and therefore produce bioconjugates that are also more hydrophilic. Such conjugates lead to better performance in diagnostic assays. Normally the labels are prepared by heating the corresponding acridine in neat 1,3- propanesultone at high temperature for several hours. In some cases this approach has failed and a more reactive sulfopropylating reagent, available only through a multistep synthesis, was used. In this work an alternative route is presented. A series of N-sulfonylacridine-9-carboxamides were heated in a consumer microwave oven with 1,3- propanesultone to afford the corresponding chemiluminescent acridinium salts. Greater than 90% conversion was achieved within eight minutes. [Poster: mattingl.philli.49601]

Return to the list of abstracts

E-mail   |  Conference Info  |   Index of Abstracts