MCDB Home > Faculty > Kenneth Kosik > Selected Publications

Original Reports

Onur Sakarya, Kathryn A. Armstrong, Maja Adamska, Marcin Adamski, I-Fan Wang, Bruce Tidor, Bernard M. Degnan, Todd H. Oakley, Kenneth S. Kosik: A Post-synaptic Scaffold at the Origin of the Animal Kingdom. PLoS One (in press)

Kumar P, Ambasta RK, Veereshwarayya V, Rosen KM, Kosik KS, Band H, Mestril R, Patterson C, Querfurth HW. CHIP and HSPs interact with {beta}-APP in a proteasome-dependent manner and influence A{beta} metabolism. Hum Mol Genet. 2007 Feb 22

Donahue CP, Muratore C, Wu JY, Kosik KS, Wolfe MS. Stabilization of the TAU exon 10 stem loop alters pre-mRNA splicing. J Biol Chem. 2006 Aug 18;281(33):23302-6. Epub 2006 Jun 16.

Donahue CP, Kosik KS, Shors TJ. Growth hormone is produced within the hippocampus where it responds to age, sex, and stress. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):6031-6. Epub 2006 Mar 30.

Krichevsky AM, Sonntag KC, Isacson O, Kosik KS. Specific microRNAs modulate ES cell-derived neurogenesis. Stem Cells. 2005 Dec 15

Monticelli S, Ansel KM, Xiao C, Socci ND, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS. MicroRNA profiling of the murine hematopoietic system. Genome Biol. 2005;6(8):R71.

Rampal R, Arboleda-Velasquez J, Nita-Lazar A, Kosik KS, Haltiwanger RS: Highly conserved O-fucose sites have distinct effects on Notch1 function. J Biol Chem. 2005, 280(37):32133-40; 2005 Jul 1; [Epub ahead of print]

Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh L-A, Kosik KS: Defining Cdk5 Ligand Chemical Space with Small Molecule Inhibitors of Tau Phosphorylation. Chemistry and Biology 2005 Jul;12(7):811-823.

Chan JA, Krichevsky AM, Kosik KS: microRNA-21 is an anti-apoptotic factor in human glioblastoma cells. Cancer Research 2005 Jul 15;65(14):6029-33

Arboleda-Velasquez JF, Rampal R, Fung E, Darland DC, M L, Martinez MC, Donahue CP, Navarro-Gonzalez MF, Libby P, D'Amore PA, Aikawa M, Haltiwanger RS, Kosik KS. CADASIL Mutations Impair Notch3 Glycosylation by Fringe. Hum Mol Genet. 2005 14(12):1631-1639; [Epub ahead of print 2005 Apr 27]

Monshausen M, Gehring NH, Kosik KS: The Mammalian RNA Binding Protein Staufen2 Links Nuclear and Cytoplasmic RNA Processing Pathways in Neurons. NeuroMolecular Medicine 2004;6(2-3):127-44.

Liu M, Jake Ni J, Kosik K.S., Yeh, L-A: Development of a Fluorescent High Throughput Assay for Tau Aggregation. Assay Drug Dev Technol. 2004 Dec;2(6):609-19.

Zhu D, Kosik KS, Meigs TE, Yanamadala V, Denker BM. G{alpha}12 Directly Interacts with PP2A: Evidence for G{alpha}12-Stimulated PP2A Phosphatase Activity and Dephosphorylation of Microtubule-Associated Protein, Tau. J Biol Chem. 2004 Dec 31;279(53):54983-54986. Epub 2004 Nov 3.

Rojas Alvarez A, Sandoval PC, Leal NR, Castro PU, Kosik KS: Activation of the Neuronal c-Abl Tyrosine Kinase by Amyloid-β-Peptide and Reactive Oxygen Species. Neurobiology of Disease 2004 Nov;17(2):326-36.

Ruiz-Opazo N, Kosik KS, Lopez LV, Bagamasbad P, Ponce LR, Herrera VL. Attenuated Hippocampus-Dependent Learning and Memory Decline in Transgenic TgAPPswe Fischer-344 Rats. Mol Med. 2004 Jan-Jun;10(1-6):36-44.

Shimura H, Miura-Shimura Y, Kosik KS. Binding of Tau to HSP27 leads to decreased concentration of hyperphosphorylated Tau and enhanced cell survival. J Biol Chem. 2004 Apr 23;279(17):17957-62. Epub 2004 Feb 12.

Ahn JS, Musacchio A, Mapelli M, Ni J, Scinto L, Stein R, Kosik KS, Yeh LA.: Development of an assay to screen for inhibitors of tau phosphorylation by cdk5. J Biomol Screen. 2004 Apr;9 (2):122-31.

Israely I, Costa RM, Xie CW, Silva AJ, Kosik KS, Liu X: The neuronal adherens-junction protein Delta-Catenin is critical for learning and synaptic plasticity. Current Biology 2004 Sep 21;14(18):1657-63

Donahue CP, Kosik KS: Distribution pattern of Notch3 mutations suggests a gain-of-function mechanism for CADASIL. Genomics 83(1):59-65, 2004.

Morin PJ, Medina M, Semenov M, Brown AM, Kosik KS.: Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP. Neurobiol Dis. 2004 Jun;16 (1):59-67.

Kao S-C, Krichevsky AM, Kosik KS and Li-Huei Tsai L-H: BACE1 Suppression by RNA Interference in Primary Cortical Neurons. J Biol Chem. 279(3):1942-9, 2004. Epub 2003 Nov 03.

Shimura H, Schwartz D, Gygi SP, Kosik KS.: CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival. J Biol Chem. 2004 Feb 6;279(6):4869-76. Epub 2003 Nov 10.

Krichevsky AM, King KS, Donahue CP, Khrapko K, Kosik KS: A microRNA array reveals extensive regulation of microRNAs during brain development. RNA 9:1274-1281, 2003.

Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G.: Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A. 2004 Jan 6; 101(1): 360-5. Epub 2003 Dec 22.

Pastor P, Roe CM, Villegas A, Bedoya G, Chakraverty S, Garcia G, Tirado V, Norton J, Rios S, Martinez M, Kosik KS, Lopera F, Goate AM. Links Abstract Apolipoprotein E varepsilon 4 modifies Alzheimer's disease onset in an E280A PS1 kindred. Ann Neurol. 54:163-9, 2003.

Martinez MC, Ochiishi T, Majewski M and Kosik KS: Dual regulation of neuronal morphogenesis by a δ-catenin-cortactin complex and Rho J. Cell Biol 162:99-111, 2003.

Krichevsky AM and Kosik KS: RNAi Functions in Cultured Mammalian Neurons. Proc National Acd Sci U S A. 99:11926-9, 2002.

Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS: Parkin Localization to the Lewy Bodies of Parkinson's Disease and Dementia with Lewy Bodies. Am J Path 160:1655-67, 2002.

J. F. Arboleda-Velasquez , F. Lopera,E. Lopez, M. P. Frosch, D. Sepulveda-Falla, J. E. Gutierrez, S. Vargas, M. Medina, C. Martinez de Arrieta, R. V. Lebo, S. A. Slaugenhaupt, R.A. Betensky, A. Villegas, M. Arcos-Burgos, D. Rivera, JC. Restrepo, KS Kosik: C455R Notch3 Mutation in a Colombian CADASIL Kindred with Early Onset of Stroke Neurology 59:277-279, 2002.

Laura RP, Witt AS, Held HA, Gerstner R, Koehler MFT, Deshayes K, Kosik KS, Sidhu SS and Lasky LA: The Erbin PDZ domain binds with high affinity and specificity to the carboxyl-termini of δ-catenin and ARVCF. J Biol Chem 277:12906-14, 2002.

Lu Q, Mukhopadhyay NK, Griffin JD, Paredes M, Medina M, Kosik KS: Brain armadillo protein delta-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors. J Neurosci Res 2002;67(5):618-24

Temple MD, Kosik KS, Steward O: Spatial mapping function in rats after early development in a microgravity environment. Neurobiology of Learning and Memory 78:199-216, 2002.

Donahue CP, Jensen RV, Ochiishi T, Eisenstein I, Zhao M, Shors, T, Kosik KS: Transcriptional Profiling Reveals Regulated Genes in the Hippocampus during Memory Formation Hippocampus 12:821-833, 2002.

Krichevsky A. and Kosik KS: Neuronal RNA Granules: A Link between RNA Localization and Stimulation-dependent Translation. Neuron 32:683-696, 2001.

Shimura H. Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik, KS*, Selkoe DJ*: Ubiquitination of a New Form of Alpha-Synuclein by Parkin from Human Brain: Implications for Parkinson Disease. Science 293:263-269, 2001 (these two authors contributed equally)

Neumann PJ, James K. Hammitt, Curt Mueller, Howard M. Fillit, Jerrold Hill, Nii A. Tetteh, Kenneth S. Kosik: Public Attitudes and Willingness to Pay for Genetic Testing for Alzheimer's disease . Health Affairs 20:252-264, 2001.

Peter J. Neumann, Sc.D. Sally S. Araki, S.M. Almudena Arcelus, Ph.D. Andrea Longo, B.S. George Papadopoulos, B.Sc. K. S. Kosik, M.D. Karen M. Kuntz, Sc.D. Ashoke Bhattacharjya, Ph.D.: Measuring Alzheimer's Disease Progression With Transition Probabilities: Estimates from CERAD Neurology 57:957-964, 2001

Johnson K, Lopera F, Jones K, Becker A , R Sperling, J Hilson, J Londono , I Siegert, M Arcos, S Moreno, L Madrigal , J Ossa, N Pineda, A Ardila, M Roselli, M Albert , KS Kosik, A Rios: Presenilin-1-Associated Abnormalities in Regional Cerebral Perfusion. Neurology 56:1545-1551, 2001.

Kunda P, Paglini G, Quiroga S, Kosik K, Caceres A: Evidence for the involvement of TIAM1 in axon formation. J. Neuroscience 21:2361-2371, 2001.

Lu M and Kosik KS: Competition for microtubule-binding with dual expression of tau missense and splice isoforms. Mol Biol Cell 12:171-184, 2001

Ardila A, Lopera F, Rosselli M, Moreno S, Madrigal L, Arango-Lasprilla JC, Arcos M, Murcia C, Arango-Viana JC, Ossa J, Goate A, Kosik KS. Neuropsychological Profile of a Large Kindred with Familial Alzheimer's Disease Caused by the E280A Single Presenilin-1 Mutation. Arch Clin Neuropsychol. 15(6):515-28, 2000.

Rook MS, Lu M, Kosik KS: CaMKIIα 3'UTR directed mRNA translocation in living neurons: visualization by GFP linkage. J. Neurosci 20:6385-6393, 2000.

Noll E, Medina M, Hartley D, Zhou J, Perrimon N, Kosik KS: Presenilin affects Arm/β-catenin localization and function in Drosophila Dev Biol 227 (2), 450-465, 2000.

Ho, C., Zhou, J., Medina, M., Goto, T., Jacobson, M., Bhide, P.G., Kosik, K.S. Expression of the neuronal specific adherens junction protein δ-catenin. J. Comp Neurol 420:261-276, 2000.

Rosselli MC, Ardila AC, Moreno SC, Standish VC, Arango-Lasprilla JC, Tirado VM, Ossa JM, Goate AM, Kosik KS, Lopera F.: Cognitive decline in patients with familial Alzheimer's disease associated with E280A presenilin-1 mutation: a longitudinal study. J Clin Exp Neuropsychol 22:483-95, 2000.

Medina M, Marinescu RC, Overhauser J and Kosik KS:δ-catenin gene deletions are associated with the mental retardation of Cri-du-Chat syndrome Genomics 63:157-164, 2000.

Teresa Gómez-Isla, Whitfield B. Growdon, Megan J. McNamara , David Nochlin, Thomas D. Bird, Juan Carlos Arango, Francisco Lopera , Kenneth Kosik, Peter L. Lantos, Nigel J. Cairns and Bradley T. Hyman. The impact of different presenilin 1 and presenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease (AD) brain: Evidence for other phenotype modifying factors. Brain 1999, 122:1709-1719

Lu Q, Paredes M, Medina M, Zhou J, Cavallo R, Peifer M, Orecchio L, Kosik KS: δ-Catenin, an adhesive junction associated protein which promotes cell scattering J. Cell Biol. 144:519-532, 1999.

Kosik K.S.: Presenilin interactions and Alzheimer's disease. (letter) Science 279:463-464, 1998.

Paglini G, Kunda P, Quiroga S, Kosik K, Caceres A: Suppression of radixin and moesin alters growth cone morphology, motility and process formation in primary cultured neurons. J. Cell Biol. 143:443-455, 1998.

Lee S-J, Liyanage U, Bickel PE, Xia W, Lansbury Jr. PT, Kosik KS: A Detergent-Insoluble Membrane Compartment Contains Aβ in vivo. Nature Medicine 4:730-734, 1998.

Ferreira A., Chin L-S, Li L., Lanier LM, Kosik KS, Greengard P: Distinct roles of synapsin I and synapsin II during neuronal development. Molecular Medicine 4:22-28, 1998.

Bassell GJ, Zhang H, Byrd AL , Femino AM, Singer RH, Taneja KL, Lifshitz LM, Herman IM, Kosik KS. Sorting of α-actin mRNA and protein to neurites and growth cones in culture. J. Neurosci. 18:251-265, 1998

Lu Q, Paredes M, Zhang J, Kosik KS: Basal ERK Activity Modulates Cell-Cell and Cell-Matrix Interactions. Molecular and Cellular Biology 18:3257-3265, 1998.

Lu M., Witke W, Kwiatkowski DJ, Kosik K.S. Delayed Retraction of Filopodia in Gelsolin Null Mice. J. Cell Biol. 138:1279-1287, 1997.

Morfini G, Quiroga S, Rosa A, Kosik K, Caceres A: Suppression of KIF2 in PC12 cells alters the distribution of a growth cone non-synaptic receptor and inhibits neurite extension. J. Cell Biol. 138:657-669, 1997.

Zhou J, Liyanage U, Medina M, Ho C, Simmons AD, Lovett M, Kosik KS:Presenilin 1 Interacts in Brain with a Novel Member of the Armadillo Family. NeuroReport 8:1489-1494, 1997 and erratum published 8: 2085-2090, 1997.

Lopera F, Ardilla A, Martínez A Madrigal L, Arango-Viana JC, Lemere CA,. Arango-Lasprilla JC, Hincapié L, Arcos-Burgos M, Ossa JE, Behrens IM, Norton J, Lendon C, Goate A, Ruiz-Linares A, Rosselli M, Kosik KS: Phenotypic Features of a Very Large Kindred With a E280A Presenilin 1 Mutation in Antioquia, Colombia. JAMA 277:793-799, 1997.

Flanagan LA, Cunningham CC, Kosik KS, Janmey PA. The structures of divalent cation- induced aggregates of PIP2 and their alteration by the phosphoinositide-binding proteins gelsolin and tau. Biophys J 1997, 73:1440-1447.

Lendon CL, Martinez A, Behrens IM, Kosik KS, Madrigal L, Norton J, Neuman R, Myers A, Busfield F, Ruiz A, Wragg M, Arcos M, Arango Viana JC, Ossa J, Ruiz A, Goate AM, Lopera F. The E280A PS-1 mutation causes Alzheimer's but age of disease onset is not determined by ApoE alleles. Human Mutation 1997, 10: 186-195.

Hall GF, Yao J, Selzer ME, Kosik KS. Cytoskeletal Changes Correlated With the Loss of Neuronal Polarity In Axotomized Lamprey Central Neurons. J. Neurocyt 26:733-753, 1997.

Knowles R, Kosik KS. Effects of neurotrophin-3 on distribution of RNA granules in cortical neurons. Proc. Natl. Acad. Sci. 94:14804-14808, 1997.

Cunningham CC, Leclerc N, Flanagan L, Lu M,Janmey PA, Kosik KS. MAP2c reorganizes both microtubules and microfilaments into distinct cytological structures in an ABP-280 deficient melanoma cell line. J. Cell Biol. 136:845-857, 1997.

Knowles R, Sabry J, Martone ME, Deerinck TJ, Ellisman MH, Bassell GJ, Kosik KS. Translocation of RNA granules in living neurons. J. Neurosci 16:7812-7820, 1996.

Ferreira A, Lian L, Chin L-S, Greengard P, Kosik KS. Postsynaptic element contributes to the delay in synaptogenesis in synapsin I-deficient neurons. Mol Cell Neuroscience 8:286-299, 1996.

Lemere CA, Lopera F, Kosik KS, Lendon C, Ossa J, Saido T, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, Selkoe DJ, Arango V, JC. The E280A presenilin 1 mutation leads to a distinct Alzheimer's disease phenotype: Increased Abeta42 deposition and severe cerebellar pathology. Nature Med. 1996; 2:1146-1150.

Ferreira A, Kosik KS. Accelerated neuronal differentiation induced by p53 suppression. J Cell Sci. 1996; 109:1509-1516.

Morishima-Kawashima M, Kosik KS. The pool of MAP kinase associated with microtubules is small but constitutively active. Mol Biol Cell 1996; 7:893-905.

DiTella MC, Feiguin F, Carri N, Kosik KS, Caceres A. MAP-1B/tau functional redundancy during laminin-enhanced axonal growth. J Cell Sci. 1996; 109:467-477.

Andreadis A, Wagner B, Broderick JA, Kosik KS. A tau promoter region lacks neuronal specificity. J Neurochem. 1996; 66:2257-2263.

Leclerc N, Baas PW, Garner C, Kosik KS. Juvenile and mature MAP2 isoforms induce distinct cellular morphologies. Mol Biol Cell 1996; 7:443-455.

Greenberg SM, Qui WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. Amino-terminal region of the β-amyloid precursor protein activates mitogen-activated protein kinase. Neurosci Lett. 1995; 198:52-56.

Mercken M, Fischer I, Kosik KS, Nixon RA. Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo. J Neurosci. 1995; 15:8259-8267.

Andreadis A, Broderick JA, Kosik KS. Relative exon affinities and suboptimal splice site signals lead to non-equivalence of two cassette exons. Nucleic Acids Res. 1995; 23:3585-3593.

Clark RF et al.(Alzheimer's disease collaborative group). The structure of the presenilin 1 (S182) gene and and identification of six novel mutations in early onset AD families. Nature Gen. 1995; 11:219-222.

Chin L-S, Li L, Ferreira A, Kosik KS, Greengard P. Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. Proc Natl Acad Sci USA 1995; 92:9230-9234.

Ferreira A, Han H-Q, Greengard P, Kosik KS. Suppression of synapsin II inhibits the formation and maintenance of synapses in hippocampal culture. Proc Natl Acad Sci USA 1995; 92:9225-9229.

Lopera F, Arcos M, Madrigal L, Kosik KS, Cornejo W, Ossa J. Demencia tipo Alzheimer con agregacion familiar en Antioquia, Colombia. Acta Neurol Colomb. 1994; 10:173-187.

Feiguin F, Ferreira A, Kosik KS, Caceres A. Kinesin-mediated organelle translocation revealed by specific cellular manipulations. J Cell Biol. 1994; 127:1021-1039.

Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Secreted β-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances t phosphorylation. Proc Natl Acad Sci USA 1994; 91:7104-7108.

Ferreira A, Kosik KS, Greengard P, Han H-Q. Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons. Science 1994; 264:977-979.

Knowles R, Leclerc N, Kosik KS. Organization of actin and microtubules during process formation in tau-expressing Sf9 cells. Cell Motil Cytoskel. 1994; 28:256-264.

Bassell GJ, Singer RH, Kosik KS. Association of neuronal poly-A mRNA with microtubule populations. Neuron 1994; 12:571-582.

Baas PW, Pienkowski TP, Cimbalnik KA, Toyama K, Bakalis S, Ahmad FJ, Kosik KS. Tau confers drug-stability but not cold stability to microtubules in living cells. J. Cell Science 107:135-143, 1994.

Watanabe A, Hasegawa M, Suzuki M, Takio K, Morishima-Kawashima M, Titani K, Arai T, Kosik KS, Ihara Y. In vivo phosphorylation sites in fetal and adult tau. J Biol Chem. 1993;268:25712-25717.

Ferreira A, Kincaid R, Kosik KS. Calcineurin is associated with the cytoskeleton of cultured neurons and has a role in the acquisition of polarity. Mol Biol Cell 1993; 4:1225-1238.

Amaratunga A, Morin PJ, Kosik KS, Fine RE. Inhibition of kinesin synthesis and rapid anterograde axonal transport in vivo by an antisense oligonucleotide. J Biol Chem. 1993; 268:17427-17430.

Andreadis A, Nisson PE, Kosik KS, Watkins PC. The exon trapping assay partly discriminates against alternatively spliced exons. Nucleic Acids Research 1993; 21:2217-2221.

Hall G, Kosik KS. Axotomy-induced neurofilament phosphorylation can be blocked in situ by microinjection of protein kinase C inhibitors into identified lamprey neurons. Neuron 10:613-625, 1993.

Markesbery WR, Wang HZ, Kowall NW, Kosik KS, McKee AC. Morphometric image analysis of neuropil threads in Alzheimer's disease. Neurobiology of Aging 1993; 14:303-307.

Ferreira A, Caceres A, Kosik KS. Intraneuronal compartments of the amyloid precursor protein. J Neurosci. 1993; 13:3112-3123.

Leclerc N, Kosik KS, Cowan N, Pienkowski TP, Baas PW. Process formation in Sf9 cells induced by the expression of a MAP2C-like construct. Proc Natl Acad Sci USA 1993; 70:6223-6227.

Andreadis A, Brown WM, Kosik KS. Structure and novel exons of the human tau gene. Biochemistry 1992; 31:10626-10633.

Caceres A, Mautino J, Kosik KS. Suppression of MAP-2 in cultured cerebellar macroneurons inhibits minor neurite formation. Neuron 1992; 9:607-618.

Cheley S, Kosik KS, Paskevich P, Bakalis S, Bayley H. Phosphorylated baculovirus p10 is a heat-stable microtubule-associated protein associated with process formation in Sf9 cells. J Cell Sci. 1992; 102:739-752.

Gallo JM, Hanger DP, Twist EC, Kosik KS, Anderton BH. Expression and phosphorylation of a three-repeat isoform of tau in transfected cells. Biochem J. 1992; 286:399-404.

Ferreira A, Niclas J, Vale RD, Banker G, Kosik KS. Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides. J Cell Biol. 1992; 117:595-606.

Baas PW, Pienkowski TP, Kosik KS. Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization. J Cell Biol. 1991; 115:1333-1344.

Morishima-Kawashima M, Arai T, Ogawara M, Takio K, Titani K, Saitoh T, Kosik KS, Ihara Y. A possible fetal antigen of Mr 70,000 in neurofibrillary tangles. Brain Res. 1991; 554:316-320.

Oblinger MM, Argasinski A, Wong J, Kosik KS: Tau gene expression in rat sensory neurons during development and regeneration. J Neurosci.1991, 11:2453-2459.

Knops J, Kosik KS, Lee G, Pardee JD, Cohen-Gould L, McConlogue L: Overexpression of tau in a non-neuronal cell induces long cellular processes. J Cell Biol. 1991; 114:725-733.

Caceres A, Potrebic S, Kosik KS. The effect of tau antisense oligonucleotides on neurite formation of cultured cerebellar macroneurons. J Neurosci. 1991, 11:1515-1523.

McKee AC, Kosik KS, Kowall NW. Neuritic pathology and dementia in Alzheimer's disease. Ann Neurol. 1991; 30:156-165.

Hall GF, Lee VM-Y, Kosik KS. Microtubule destabilization and neurofilament phosphorylation precede dendritic sprouting following close axotomy of lamprey central neurons. Proc Natl Acad Sci USA 1991; 88:5016-5020.

Ueda K, Masliah E, Terry R, Saitoh T, Bakalis SL, Scoble H, Kosik KS. Alz-50 recognizes a phosphorylated epitope of tau protein. J Neurosci. 1990; 10:3295-3304.

Caceres A, Kosik KS. Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons. Nature 1990; 343:461-463.

Kosik KS, Orecchio LD, Schnapp BJ, Inouye H, Neve RL. The primary structure and analysis of the squid kinesin heavy chain. J Biol Chem. 1990; 265:3278-3283.

McKee AC, Kowall NW, Kennedy MB, Kosik KS. Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase. J Neuropathol Exp Neurol. 1989; 49:49-63.

McKee AC, Kowall NW, Kosik KS. Microtubular reorganization and growth response in Alzheimer's disease. Ann Neurol. 1989; 26:652-659.

Kosik KS, Crandall JE, Mufson E, Neve RL. Tau in situ hybridization in normal and Alzheimer brain: Localization in the somatodendritic compartment. Ann Neurol. 1989; 26:352-361.

Lee G, Neve RL, Kosik KS. The microtubule binding domain of tau protein. Neuron 1989; 2:1615-1624.

Shankar SK, Yanagihara R, Garruto RM, Grundke-Iqbal I, Kosik KS, Gajdusek DC. Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and Parkinson-dementia of Guam. Ann Neurol. 1989; 25:146-151.

Kosik KS, Orecchio LD, Bakalis S, Neve RL. Developmentally regulated expression of specific tau sequences. Neuron 1989; 2:1389-1397.

Talamo BR, Rudel R, Kosik KS, Lee V, Neff S, Adelman L, Kauer JS. Pathological changes in olfactory neurons in patients with Alzheimer's disease. Nature 1989; 337:736-739.

Kosik KS, Orecchio LD, Binder LI, Trojanowski J, Lee V, Lee G. Epitopes that span the tau molecule are shared with paired helical filaments. Neuron 1988; 1:817-825.

Kosik KS, Orecchio LD, Bruns G, Benowitz LI, MacDonald GP, Cox DR, Neve RL. Human GAP-43: Its deduced amino acid sequence and chromosomal localization in mouse and human. Neuron 1988; 1:127-132.

Nukina N, Kosik KS, Selkoe DJ. The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain. Neurosci Lett. 1988; 87:240-246.

Sims KB, Crandall JE, Kosik KS, Williams RS. Microtubule-associated protein 2 (MAP2) immunoreactivity in human fetal neocortex. Brain Res. 1988; 449:192-200.

Kosik KS, Orecchio LD, Bakalis S, Duffy L, Neve RL. Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles. J Neurochem. 1988; 51:587-598.

Kowall NW, Kosik KS. Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease. Ann Neurol. 1987; 22:639-643.

Fischer I, Kosik KS, Sapirstein VS. Heterogeneity of microtubule-associated protein (MAP2) in vertebrate brains. Brain Res. 1987; 436:39-48.

Joachim CL, Morris JH, Selkoe DJ, Kosik KS. Tau epitopes are incorporated into a range of lesions in Alzheimer's disease. J Neuropath Exp Neurol. 1987; 46:611-622.

Joachim CL, Morris JH, Kosik KS, Selkoe, DJ. Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders. Ann Neurol. 1987; 22:514-520.

Kosik KS, Finch EA. MAP2 and tau segregate into axonal and dendritic domains after the elaboration of morphologically distinct neurites: An immunocytochemical study of cultured rat cerebrum. J Neurosci. 1987; 7:3142-3153.

Nukina N, Kosik KS, Selkoe DJ. Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein. Proc Natl Acad Sci USA 1987; 84:3415-3419.

Galloway PG, Perry G, Kosik KS, Gambetti P. Hirano bodies contain tau protein. Brain Res. 1987; 403:337-340.

Kosik KS, Rogers J, Kowall N. Senile plaques are located between apical dendritic clusters. J Neuropathol Exp Neurol. 1987; 46:1-11.

Kosik KS, Joachim CL, Selkoe DJ. Microtubule-associated protein tau (τ) is a major antigenic component of paired helical filaments in Alzheimer's disease. Proc Natl Acad Sci USA 1986; 83:4044-4048

Crandall JE, Jacobsen M, Kosik KS. Ontogenesis of microtubule-associated protein 2 (MAP 2) in embryonic mouse cortex. Dev Brain Res. 1986; 28:127-133.

Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA. Identification of cDNA clones for the human microtubule-associated protein, tau, and chromosomal localization of the genes for tau and microtubule-associated protein 2. Molecular Brain Res. 1986; 1:271-280.

Neve RL, Selkoe DJ, Kurnit DM, Kosik KS. A cDNA for a human microtubule-associated protein 2 epitope in the Alzheimer neurofibrillary tangle. Molecular Brain Res. 1986; 1:193-196.

Kosik KS, Bakalis SF, Selkoe DJ, Pierce MW, Duffy LK. High molecular weight microtubule-associated proteins: purification by electro-elution and amino acid compositions. J Neurosci Res. 1986; 15:543-551.

Escobar MI, Pimienta H, Caviness VS, Jacobson M, Crandall JE, Kosik KS. Architecture of apical dendrites in the murine neocortex: dual apical dendritic systems. Neuroscience 1986; 17:975-989.

Fischer I, Shea TB, Sapirstein VS, Kosik KS. Expression and distribution of microtubule-associated protein 2 (MAP 2) in neuroblastoma and primary neuronal cells. Dev Brain Res. 1986; 25:99-109.

Kosik KS, McCluskey AH, Walsh FX, Selkoe DJ. Transport and synthesis of cytoskeletal proteins in aluminum toxicity. Neurochem Pathol. 1985; 3:99-108.

Kosik KS, Duffy LK, Dowling MM, Abraham C, McCluskey A, Selkoe DJ. Microtubule-associated protein 2: Monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles. Proc Natl Acad Sci USA 1984; 81:7941-7945.

Kosik KS, Selkoe DJ, Sapirstein V. Possible modifications of vimentin following acquisition of Triton insolubility. Biochem Internat. 1984; 9:483-490.

Kosik KS, Bradley WG, Good PF, Rasool CG, Selkoe DJ. Cholinergic function in lumbar aluminum myelopathy. J Neuropathol Exp Neurol. 1983; 42:365-375.

Kosik KS, Gilbert JM, Selkoe DJ, Strocchi P. Characterization of postmortem human brain proteins by two-dimensional gel electrophoresis. J Neurochem. 1982; 39:1529-1538.

Selkoe DJ, Salazar FJ, Abraham C, Kosik KS. Huntington's disease: Biochemical and immunological characterization of altered striatal proteins. Brain Res. 1982; 245:117-135.

Kosik KS, Furie B. Thrombotic stroke associated with elevated plasma factor VIII. Ann Neurol. 1980; 8:435-437.

Kosik KS, Mullins TF, Bradley WG, Tempelis LD, Cretella A. Coma and axonal degeneration in vitamin B12 deficiency. Arch Neurology 1980; 37:590-592.

Reviews

Kosik K.S. The Neuronal microRNA System. Nat Rev Neurosci. 2006 Dec;7(12):911-20.

Kosik K.S. Traveling the tau pathway: a personal account. J Alzheimers Dis. 2006;9(3 Suppl):251-6.

Kosik K.S. Neuroscience gears up for duel on the issue of brain versus deity. Nature. 2006 Jan 12;439(7073):138 (correspondence).

Kosik KS, Krichevsky AM. The Elegance of the MicroRNAs: A Neuronal Perspective. Neuron. 2005 Sep 15;47(6):779-82.

Kosik KS, Krichevsky AM. A model for local regulation of translation near active synapses. Sci STKE. 2005 Sep 6;2005(300):tr25.

Goate AM, Pastor P, Roe CM, Norton J, Chakraverty S, Lopera F, Kosik KS: Identification of Genes that Modify the Age of Onset in a Large Familial Alzhiemer's Disease Kindred. In: Genotype-Prototype-Phenotype Relationships in Neurodegenerative Diseases. Eds., J Cummings, J. Hardy, M. Poncet, Y. Christen. Fondation IPSEN Berlin, Springer-Verlag, 2005 pp. 61-71.

Kosik, K.S., Donahue, CP, Israely I, Lu X, Ochiishi T: ?-catenin at the Synaptic-Adherens Junction. Trends Cell Biol. 2005 Mar;15(3):172-8.

Kosik KS, Shimura H. Phosphorylated tau and the neurodegenerative foldopathies. Biochim Biophys Acta. 2005 Jan 3;1739(2-3):298-310. Epub 2004 Nov 26.

Kosik, K.S. Another Tau Mutation, Another Insight. Journal Watch Neurology 6:19, 2004.

Kosik, K.S.: The Evolution of the Human Brain. Psychiatric Times 20:50-55, 2003.

Kosik KS: Beyond Phrenology, At Last. Nature Reviews Neuroscience 4:234-239, 2003.

Kosik KS, Ahn J, Stein R., Yeh L-A: Discovery of Compounds That Will Prevent Tau Pathology: J Mol Neurosci 19(3):261-266, 2002.

Martin K and Kosik KS: Synaptic Tagging: Who's It? Nature Reviews Neuroscience 3:813-20, 2002.

Kosik, K.S. A Boost for NSAIDs in Alzheimer Prevention. Journal Watch Neurology 4:35, 2002.

Kosik K.S. and Krichevsky AM: The Message and the Messenger: Delivering RNA in Neurons. Science stke Perspective www.stke.org/cgi/content/full/OC_sigtrans;2002/126/pe16

Kosik, K.S.: A More Perfect Astronaut: Can biologists make their mark on space research? Air and Space p 62, July 2001

Kosik, K.S.: The High Flying Genome. Bioessays 23: 203-205, 2001.

Kosik, K.S.: The Long Reach of Evolution and Development: Effects on the Alzheimer Brain. In Alzheimer's Disease: A Compendium of Theories, ed by Z.S. Khachaturian and M. Marsel Mesulam, Annals of New York Acad of Sciences Vol 924 pp76-80, 2000.

Kosik, K.S., Post S.G., Quaid K.A.: An ethical context for presymptomatic testing in Alzheimer's disease. In: Scinto L.F.M. and Dafner K.R., eds. Early Diagnosis of Alzheimer's Disease. Humana Press, Inc., Totowa, NJ 2000.

Lansbury PT Jr. and Kosik KS: Neurodegeneration: New Clues on Inclusions. Chemistry and Biology 7:R9-R12, 2000.

Kosik, K.S. Of Genotypes and Phenotypes: A Tau Mutation and Dementia. Journal Watch Neurology 1:37, 1999.

Kosik, K.S. The Fortune Teller. The Sciences : July/Aug pp.13-17, 1999 (anthologized in Physical Anthropology, Annual Editions, Elvio Angeloni, editor, 10th edition, 2002)

Kosik, K. S. A notable cleavage: Winding up with Aβ. Proc Natl Acad Sci 96:2574-2576, 1999.

Kosik, K.S. A partnership that delivers. Nature Med 5:149-150, 1999.

Kosik KS, Ho C, Liyange U, Lemere C, Medina M, Zhou J: A novel gene in the armadillo family interacts with presenilin 1. In: Wang E and Snyder DS, eds. Handbook of the Aging Brain. Academic Press, San Diego 1998, pp.171-180.

Kosik, K.S. Neurolab: Learning how the nervous system adapts to microgravity. NeuroScience News 1:36-38, 1998

Kosik KS. Tau: Structure and function. In: Avila J., Brandt R., Kosik KS. (eds) Brain Microtubule Associated Proteins. Harwood Academic Publishers, Amsterdam, 1997, pp. 43-52.

Kosik KS, Ferreira A, Knowles R, Leclerc N, Greenberg SM: Linking amyloid precursor protein processing and tau-related pathology in Alzheimer's disease. In: Kosik KS, Christen Y, Selkoe DJ eds., Alzheimer's Disease: Lessons from Cell Biology, Berlin, Springer-Verlag, 1995, pp. 230-240. Kosik KS, Ferreira A, Knowles R, Leclerc N, Greenberg SM. Relation entre la maturation du precurseur de l'amyloide et la pathologie associee a tau. Alzheimer Actualites 1995; 98:6-12 (French translation of the above).

Kosik KS. The Alzheimer's Disease Sphinx: A Riddle with Plaques and Tangles. J Cell Biology 1994; 127:1501-1504.

Kosik KS. Alzheimer's Disease: Which way is forward? Neurobiology of Aging 1994; 15:S91-S92.

Kosik KS. Cellular and molecular perspectives on the microtubule-associated protein tau. In: Jolles G and Stutzmann JM, eds., Neurodegenerative Diseases, Academic Press Ltd, London, 1994, pp.81-89.

Kosik KS. and McConlogue L. Microtubule-associated protein function: lessons from expression in Spodoptera frugiperda cells. Cell Motility and Cytoskeleton 28:195-198, 1994.

Kosik KS and Greenberg SM. Tau protein and Alzheimer disease. In: Terry RD, Katzman R, Bick KL, eds., Alzheimer Disease. Raven Press, New York, 1994, pp.335-344.

Kosik KS. The molecular and cellular biology of tau. Brain Pathology 1993; 3:39-43

Kosik KS. Journal review of Brain Pathology, Nature 1992; 359:446.

Kosik KS. Cellular aspects of Alzheimer neurofibrillary pathology. In: Nadel L and Epstein CJ, eds., Down Syndrome and Alzheimer Disease. Wiley-Liss, Inc. New York, 1992, pp.183-193.

Kosik KS. Alzheimer's disease from a cell biological perspective. Science 256:780-783, 1992.

Kosik KS. Tau protein and neurodegeneration. Molecular Neurobiology 1992, 4:171-179.

Kosik KS. and Caceres A. Tau protein and the establishment of an axonal morphology. J Cell Science (supplement) 15:69-74, 1991.

Kosik KS. AD: The tangle unravels. Neuroscience Facts 2:3, 1991

Kosik KS. Alzheimer plaques and tangles: Advances on both fronts. Trends in Neuroscience 14:218-219, 1991.

Talamo BR, Feng WH, Perez-Cruet M, Adelman L, Kosik K, Lee VMY, Cork LC, Kauer JS. Pathological changes in olfactory neurons in Alzheimer's disease. In: Growden JH, Corkin S, Ritter-Walker E, Wurtman RJ, eds. Aging and Alzheimer's disease, Ann NY Acad Sci. Vol. 640, New York: N.Y. Acad Sci. 1-7, 1991.

Kosik KS. The neuritic dystrophy of Alzheimer's disease. In: Miyatake T, Selkoe DJ, Ihara Y, eds., Molecular Biology and Genetics of Alzheimer's Disease. Elsevier Science Publishers, 1990, pp.37-45.

Kosik KS. Toward cellular mechanisms of cytoskeletal inclusions in neuro-degenerative diseases. In: Segal HL, Rothstein M, Bergamini E, eds., Protein Metabolism in Aging. Wiley-Liss, Inc. New York, Modern Aging Research series 9:43-54, 1990.

Kosik KS. Alzheimer's disease: A view toward the neurites. In: Rothstein M., ed., Review of Biological Research in Aging. Wiley-Liss, Inc., New York 4:337-347, 1990.

Kosik KS. Tau protein and Alzheimer's disease. Current Opinion in Cell Biology. 2:101-104, 1990.

Kosik KS, Selkoe DJ. Probes for the molecular components of plaques and tangles point to a broadening view of Alzheimer pathology. In: Boller F et al., eds., Biological Markers of Alzheimer's Disease. (Fondation IPSEN) Springer-Verlag Berlin, 1989, pp.30-38.

Selkoe DJ, Podlisny MB, Gronbeck A, Mammen A, Kosik KS. Molecular relation of amyloid filaments and paired helical filaments in Alzheimer's disease. In: Wurtman et al., eds., Advances in Neurology Vol. 51: Alzheimer's Disease, Raven Press, New York, 1990, pp. 171-179.

Kosik KS. Pyramidal cell topography of microtubule-associated proteins and their precipitation into paired helical filaments. In: Khachaturian ZS et al., eds., Ann NY Acad Sci. 1989; 568:125-130.

Selkoe DJ, Duffy LK, Nukina N, Podlisny MB, Abraham C, Kosik KS. Molecular pathology of intra- and extraneuronal filaments in brain aging and Alzheimer's disease. In: Miner GD et al., eds., Familial Alzheimer's Disease. Marcel Dekker, Inc., New York, 1989, pp.137-151.

Kosik KS. Alz 50. Drugs of the Future 1989; 14:107-108.

Kosik KS. MINIREVIEW: The molecular and cellular pathology of Alzheimer neurofibrillary lesions. J Gerontol.: Biological Sciences 1989; 44:55-58.

Kosik KS, Kowall NW, McKee A. Along the way to a neurofibrillary tangle: A look at the structure of tau. Annals of Medicine (Finland), 1989; 21:109-112.

Kosik KS, Selkoe DJ. Studies of the beta-amyloid precursor protein in brain and the pathological transformation of tau into the neurofibrillary tangle. In: Sinet PM, Lamour Y, Christen Y, eds., Genetics and Alzheimer's Disease, Berlin, Springer-Verlag, 1988, pp. 164-173.

Selkoe DS, Duffy LK, Nukina N, Joachim CL, Podlisny MB, Kosik KS. Biochemical analysis of amyloid filaments and paired helical filaments and their respective contributions to neuronal degeneration in Alzheimer's disease. In: Davies P, Finch CE, eds., Banbury Report 27: Molecular Neuropathology of Aging, New York: Cold Spring Harbor Laboratory, 1987, pp. 235-252.

Kosik KS and Neve R. Cloning of neurofibrillary tangle-related genes. In: Perry G, ed. Alteration of the Neuronal Cytoskeleton in Aging and Dementia. New York, Plenum Publishing Corporation, 1987.

Quattrochi JJ, Madison R, Kljavin IJ, Marsala J, Kosik KS. Integrative structural correlates of central respiratory rhythmicity: a new hypothesis. In: von Euler C, Lagercrantz H, ed. Neurobiology of the Control of Breathing. New York, Raven Press, Inc., 1986.

Selkoe DJ, Abraham C, Rasool CG, McCluskey A, Kosik KS, Duffy LK. Paired helical filaments in human neurons: Relationship to neurofilaments. Ann NY Acad Sci. 1985; 455:583-596.

Kosik KS, Ihara Y, Abraham C, Rasool CG, McCluskey A, Selkoe DJ. Neurochemical studies of Alzheimer-type neurofibrillary degeneration and a related experimental model. In: Scarpelli D, ed. Comparative Pathobiology of Major Age-Related Diseases: Current Status and Research Frontiers. New York, Alan R. Liss, Inc., 1984, pp. 373-384.

Selkoe DJ, Kosik KS. Neurochemical changes with aging. In: Albert M, ed. Clinical Neurology of Aging. New York: Oxford University Press, 1983.

Kosik KS, Selkoe DJ. Experimental models of neurofibrillary disease. In: Marotta C, ed. Neurofilaments. Minneapolis: Minnesota Press, 1983.

Kosik KS, Growdon J. Aging, memory and dementia. Psychosomatics 1982; 23:748-751.

Selkoe DJ, Kosik KS. Twins with Alzheimer disease. (Letter). Arch Neurol. 1981; 38:785.

Kosik KS, Munsat TL. The natural history of transient ischemic attacks. Practical Cardiology 1979; 5:109-117.