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Selected Publications


Lew, J., Beaudette, K., Litwin, C.M. & Wang, J.H. (1992). Purification and characterization of a novel proline-directed protein kinase from bovine brain. J Biol Chem 267, 13383-90.

Lew, J., Winkfein, R.J., Paudel, H.K. & Wang, J.H. (1992). Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2. J Biol Chem 267, 25922-6.

Paudel, H.K., Lew, J., Ali, Z. & Wang, J.H. (1993). Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments. J Biol Chem 268, 23512-8.

Lew, J., et al. (1994). A brain-specific activator of cyclin-dependent kinase 5. Nature 371, 423-6.

Lew, J. & Wang, J.H. (1995). Neuronal cdc2-like kinase. Trends Biochem Sci 20, 33-7.

Prowse, C.N., Hagopian, J.C., Cobb, M., Ahn, N.A. and Lew, J. (2000) Catalytic Reaction Pathway for the Mitogen-Activated Protein Kinase, ERK2. Biochemistry 39, 6258-66.

Hagopian, J.C., Kirtly, M., Stevenson, L., Gergis, R., Russo, A., Pavletich, N., Parsons, S. and Lew, J. (2001) Mechanism of Activation of Cdk2/cyclinA by Phosphorylation J. Biol. Chem. 276(1) 275-80.

Prowse, C.N. and Lew, J. (2001) Mechanism of Activation of ERK2 by Dual Phosphorylation. J. Biol. Chem. 276(1) 99-103.

Prowse, C.N., Deal, M.S. and Lew, J. (2001) The Complete Pathway for Catalytic Activation of the Mitogen-Activated Protein Kinase, ERK2 J. Biol. Chem 276(44) 40817-23.

Stevenson, L.M., Hagopian, J.C., Deal, M.S and Lew, J. (2002) Activation Mechanism of Cdk2/cyclinA: Role of cyclin binding versus phosphorylation. Biochemistry 41, 8528-34.

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