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Microbial Pathogenesis and Vaccine Development

Segall, A., M. J. Mahan, and J. R. Roth. (1988). Rearrangement of the bacterial chromosome: forbidden inversions. Science 241:1314-1318.

Mahan, M. J., J. M. Slauch, and J. J. Mekalanos. (1993). Selection of bacterial virulence genes that are specifically induced in host tissues. Science 259:686-688.

Mahan, M. J., J. W. Tobias, J. M. Slauch, P. C. Hanna, J. R. Collier, and J. J. Mekalanos. (1995). Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host. Proc. Natl. Acad. Sci. USA 92: 669-673.

Heithoff, D. M., C. P. Conner, P. C. Hanna, S. M. Julio, U. Hentschel, and M. J. Mahan. (1997). Bacterial infection as assessed by in vivo gene expression. Proc. Natl. Acad. Sci. USA. 94:934-939.

Conner, C. P., D. M. Heithoff, S. M. Julio, R. L. Sinsheimer, and M. J. Mahan. (1998). Differential patterns of acquired virulence genes distinguish Salmonella strains. Proc. Natl. Acad. Sci. USA 95:4641-4645.

Heithoff, D. M., R. L. Sinsheimer, D. A. Low, and M. J. Mahan. (1999). An essential role for DNA adenine methylation in bacterial virulence. Science 284:967-970.

Heithoff, D. M., C. P. Conner, U. Hentschel, F. Govantes, P. C. Hanna, and M. J. Mahan. (1999). Coordinate intracellular expression of Salmonella genes induced during infection. J. Bacteriol. 181:799-807.

Mahan, M. J., D. M. Heithoff, R. L. Sinsheimer, and D. A. Low. (2000). Assessment of bacterial pathogenesis by analysis of gene expression in the host. Annu. Rev. Genet. 34:139-164.

Heithoff, D. M., E. Y. Enioutina, R. A. Daynes, R. L. Sinsheimer, D. A. Low, and M. J. Mahan (2001). Salmonella DNA adenine methylase mutants confer cross-protective immunity. Infect Immun. 69:6725-6730.

Julio, S. M., D. M. Heithoff, D. Provenzano, K. E. Klose, R. L. Sinsheimer, D. A. Low, and M. J. Mahan. (2001). DNA adenine methylase is essential for viability and plays a role in the pathogenesis of Yersinia pseudotuberculosis and Vibrio cholerae. Infect Immun. 69:7610-7615.

Dueger, E. L., J. K. House, D. M. Heithoff, and M. J. Mahan. (2001). Salmonella DNA adenine methylase mutants elicit protective immune responses to homologous and heterologous serovars in chickens. Infect. Immun. 69:7950-7954.

Low, D. A., N. J. Weyand, and M. J. Mahan. (2001). The roles of DNA methylation in the control of bacterial gene expression and virulence. Infect. Immun. 69:7197-7204.

Julio, S. M., D. M. Heithoff, R. L. Sinsheimer, D. A. Low, and M. J. Mahan. (2002). DNA adenine methylase overproduction in Yersinia pseudotuberculosis alters YopE expression, secretion, and host immune responses to infection. Infect. Immun. 70:1006-1009.

Shtrichman, R., D. M. Heithoff, M. J. Mahan, and C. E. Samuel. (2002). Tissue selectivity of interferon-stimulated gene (ISG) expression in mice infected with Dam⁺ versus Dam^- Salmonella. Infect. Immun. 70:5579-5588.

Dueger, E. L., J. K. House, D. M. Heithoff, and M. J. Mahan. (2003). Salmonella DNA adenine methylase mutants prevent colonization of newly hatched chickens by homologous and heterologous serotypes. Intl. J. Food Microbiol. 80:153-159.

Dueger, E. L., J. K. House, D. M. Heithoff, and M. J. Mahan. (2003). Salmonella DNA adenine methylase mutants elicit early and late protective immune responses in calves. Vaccine 21:3249-3258.

Heithoff, D. M., and M. J. Mahan. (2004). Vibrio cholerae biofilms: stuck between a rock and a hard place. J. Bacteriol. 186:4835-4837.

Badie, G., D. M. Heithoff, and M. J. Mahan. (2004). LcrV synthesis is altered in DNA adenine methylase overproducing Y. pseudotuberculosis and is required to confer immunity in vaccinated hosts. Infect. Immun. Infect Immun.72:6707-6710.

V. L. Mohler, D. M. Heithoff, M. J. Mahan, K. H. Walker, M. A. Hornitzky, C. S. McConnell, L. W. C. Shum, and J. K. House. (2005). Cross-protective immunity in calves conferred by a DNA adenine methylase deficient Salmonella enterica serovar Typhimurium vaccine. Vaccine. in press.

Badie G, Heithoff DM, Sinsheimer RL, Mahan MJ. Altered Levels of Salmonella DNA Adenine Methylase Are Associated with Defects in Gene Expression, Motility, Flagellar Synthesis, and Bile Resistance in the Pathogenic Strain 14028 but Not in the Laboratory Strain LT2. J Bacteriol. 2007 Mar;189(5):1556-64.