MCDB Home > Faculty > Daniel E. Morse > Selected Publications

Biomolecular Materials, Biomineralization and Biomimetic Synthesis Morse, D.E., M.A. Cariolou, G.D. Stucky, C. M. Zaremba, and P.K. Hansma, (1993) Genetic coding in biomineralization of microlaminate composites. Materials Res. Soc. Proc. 292: 59-67.

Fritz, M., A.M. Belcher, M. Radmacher, D.A. Walters, P.K. Hansma, G.D. Stucky, D.E. Morse, and S. Mann (1994) Flat pearls from biofabrication of organized composites on inorganic substrates. Nature 371: 49-51.

Manne, S., C.M. Zaremba, R. Giles, L. Huggins, D.A. Walters, A. Belcher, D.E. Morse, G.D. Stucky, J.M. Didymus, S. Mann, and P.K. Hansma (1994) Atomic force microscopy of the nacreous layer in mollusc shells. Proc. Royal Soc. London, B 256: 17-23.

Giles, R., S. Manne, C.M. Zaremba, A. Belcher, S, Mann, D.E. Morse, G. Stucky and P.K. Hansma (1994) Imaging single nacreous tablets with the atomic force microscope. Materials. Res. Soc. Symp. Proc. 332: 413-422.

Belcher, A.M., X.C. Wu, R.J. Christensen, P.K. Hansma, G.D. Stucky and D.E. Morse (1996) Fidelity of CaCO₃ crystal phase-switching and orientation controlled by shell proteins. Nature. 381: 56-58.

Zaremba, C.M., A.M. Belcher, M. Fritz, Y.L. Li, S. Mann, P.K. Hansma, D.E. Morse, J.S. Speck and G.D. Stucky (1996) Critical transitions in the biofabrication of abalone shells and flat pearls. Chem. Materials. 8: 679-690.

Walters, D.A., B.L. Smith, A. M. Belcher, G.T. Paloczi, G.D. Stucky, D.E. Morse, and P.K. Hansma (1997) Modification of calcite crystal growth by abalone shell proteins: An atomic force microscope study. Biophysical Journal.72: 1425-1433.

Schaeffer, T.E., C. Ionescu-Zanetti, R. Proksch, M. Fritz, D.A. Walters, N. Almqvist, C.M. Zaremba, A.M. Belcher, B.L. Smith, G.D. Stucky, D.E. Morse and P.K. Hansma (1997) Does abalone nacre form by heteroepitaxial nucleation or by growth through mineral bridges? Chem. Mater. 9: 1731-1740.

Shen, X., A.M. Belcher, P.K. Hansma, G.D. Stucky, and D.E. Morse (1997) Molecular cloning and characterization of Lustrin A, a matrix protein from shell and pearl nacre of Haliotis rufescens. J. Biol. Chem. 272: 32472-32481.

Belcher, A.M., P.K. Hansma, G.D. Stucky and D.E. Morse (1998) First steps in harnessing the potential of biomineralization as a route to new high-performance composite materials. Acta Mater. 46: 733-736.

Fritz, M. and D.E. Morse (1998) The formation of highly organized biogenic polymer/ceramic composite materials: The high-performance microlaminate of molluscan nacre. Curr. Opin. Colloid Interface Sci. 3: 55-62.

Zaremba, C.M., D.E. Morse, S. Mann, P.K. Hansma, and G.D. Stucky. (1998) Aragonite-hydroxyapatite conversion in gastropod (abalone) nacre. Chem. Materials. 10: 3813-3824.

Shimizu, K., J. Cha, G.D. Stucky and D.E. Morse (1998) Silicatein α: Cathepsin L-like protein in sponge biosilica. Proc. Natl. Acad. Sci. 95: 6234-6238.

Cha, J.N., K. Shimizu, Y. Zhou, S.C. Christiansen, B.F. Chmelka, G.D. Stucky and D.E. Morse. (1999) Silicatein filaments and subunits from a marine sponge direct the polymerization of silica and silicones in vitro. Proc. Natl. Acad. Sci. USA 96: 361-365.

Zhou, Y., K. Shimizu, J.N. Cha, G.D. Stucky and D.E. Morse. (1999) Efficient catalysis of polysiloxane synthesis by Silicatein α requires specific hydroxy and imidazole functionalities. Angewandte Chemie Intl. Ed. 38: 779-782.

Morse, D.E. (1999) Silicon biotechnology: Harnessing biological silica production to make new materials. Trends in Biotechnology 17: 230-232.

Smith, B.L., T.E. Schäffer, M. Viani, J.B. Thompson, N.A. Frederick, J. Kindt, A. Belcher, G.D. Stucky, D.E. Morse and P.K. Hansma. (1999) Molecular mechanistic origin of the toughness of natural adhesives, fibers and composites. Nature 399: 761-763.

Almqvist, N., N.H. Thomson, B.L. Smith, G.D. Stucky, D.E. Morse, and P.K. Hansma. (1999) Methods for fabricating and characterizing a new generation of biomimetic materials. Mater. Sci. Eng. C 7: 34-43.

Morse, D.E. (2000) Silicon biotechnology: Proteins, genes and molecular mechanisms controlling biosilica nanofabrication offer new routes to polysiloxane synthesis. In: "Organosilicon Chemistry IV: from Molecules to Materials" (N. Auner and J. Weis, eds.); Wiley-VCH, New York; pp. 5-16.

Cha, J.N., G.D. Stucky, D.E. Morse, T.J. Deming (2000) Biomimetic synthesis of ordered silica structures by block copolypeptides. Nature 403: 289-292.

Stevens, R.M.D., N.A. Frederick, B.L. Smith, D.A. Walters, D.E. Morse, G.D. Stucky and P.K. Hansma (2000) Carbon nanotubes as probes for atomic force microscopy. Nanotechnology 11: 1-5.

Cha, J.N., K. Shimizu, Y. Zhou, S.C. Christiansen, B.F. Chmelka, T.J. Deming, G.D. Stucky and D.E. Morse (2000) Learning from biological systems: Novel routes to biomimetic synthesis of ordered silica structures. Materials Res. Soc. Symp. Proc. 599: 239-248.

Shimizu, K. and D.E. Morse. (2000) Biological and biomimetic synthesis of silica and other polysiloxanes. In: "Biomineralization: from Biology to Biotechnology and Medical Application" (E. Baeuerlein, ed.); Wiley-VCH, New York; pp. 207-220.

Kindt, J.H., J.B. Thompson, G.T. Paloczi, M. Michenfelder, B.L. Smith, G. Stucky, D.E. Morse, and P.K. Hansma. (2000) Angular Fourier mapping; Highlighting lattice structures without destroying original data. Materials Research Soc. Symp. 620:M4.2:1.-7.

Thompson, J.B., G.T. Paloczi, J. H. Kindt, M. Michenfelder, B.L. Smith, G.D. Stucky, D.E. Morse and P.K. Hansma. (2001) Direct observation of calcite to aragonite growth as induced abalone shell proteins. Biophys. J. 79: 3307-3312.

Morse, D.E. (2001) Biotechnology reveals new routes to synthesis and structural control of silica and polysilsesquioxanes. In: "The Chemistry of Organic Silicon Compounds" (Z. Rappoport and Y. Apeloig, eds.); John Wiley & Sons, New York, vol. 3, pp. 805-819.

Shimizu, Y. Del Amo, M.A. Brzezinski, G.D. Stucky and D.E. Morse. (2001) A novel fluorescent silica tracer for biological silicification studies. Chem. Biol. 8: 1051-1060.

Thompson, J., B. Drake, J. Kindt, D.E. Morse and P.K. Hansma. (2001) Bone indentation recovery time correlates with bond reforming time. Nature 414: 773-776.

Zhang, B., B. Wustman, D.E. Morse, and J.S. Evans. (2002) Model peptide studies of sequence regions in the elastomeric biomineralization protein, Lustrin A. I. The C-domain consensus -PG-, -NVNCT- motif. Biopolymers 63: 358-369.

Su, X., A.M. Belcher, C.M. Zaremba, D.E. Morse, G.D. Stucky and A.H. Heuer. (2002) Structural and microstructural characterization of the growth lines and prismatic microarchitecture in red abalone shell, and the microstructures of abalone "flat pearls". Chem. Mater. 14: 3106-3117.

Wustman, B.A., D.E. Morse and J.S. Evans. (2002) Structural analyses of polyelectrolyte sequence domains within the adhesive elastomeric biomineralization protein, Lustrin A. Langmuir 18: 9901-9906.

Wustman B.A., J.C. Weaver, D.E. Morse and J.S. Evans, (2003) Structure-function studies of the Lustrin A polyelectrolyte domains, RKSY and D4. Connective Tissue Res. 44 (Suppl. 1): 10-15.

Gutsmann, T., G.E. Fantner, M. Venturoni, A. Ekani-Nkodo, J.B. Thompson, J.H. Kindt, D.E. Morse, D.K. Fygenson and P.K. Hansma, (2003) Evidence that collagen fibrils in tendons are inhomogeneously structured in a tubelike manner. Biophys J. 84: 2593-2598.

Sumerel, J.L. and D.E. Morse. (2003) Biotechnological advances in biosilicification. In: Prog. Molec. Subcellular Biol. 33: "Silicon biomineralization: Biology - Biochemistry - Molecular Biology - Biotechnology" (W.E. Müller, ed.), Springer-Verlag, Berlin, pp. 225-247.

Sumerel, J.L., W. Yang, D. Kisailus, J. Weaver, J.H. Choi and D.E. Morse. (2003) Biocatalytic structure-directing synthesis of titanium dioxide. Chem. Mater. 15: 4804-4809.

Weaver, J.C. and D.E. Morse. (2003) Molecular biology of demosponge axial filaments and their roles in biosilicification. Micro. Res. Tech. 62: 356-367.

Weaver, J.C., L.I. Pietrasanta, N. Hedin, B.F. Chmelka, P.K. Hansma and D.E. Morse. (2003) Nanostructural features of demosponge biosilica. J. Structural Biol. 144: 271-281.

Michenfelder, M., G. Fu, C. Lawrence, J.C. Weaver, B.A. Wustman, L. Taranto, J.S. Evans and D.E. Morse. (2003) Characterization of two molluscan crystal-modulating biomineralization proteins and identification of putative mineral binding domains. Biopolymers 70: 522 - 533.

Gebeshuber, I.C., J.H. Kindt, J.B. Thompson, Y. Del Amo, H. Stachelberger, M.A. Brzezinski, G.D. Stucky, D.E. Morse and P.K. Hansma. (2003) Atomic force microscopy study of living diatoms in ambient conditions. J. Microscopy 212: 292-299.

Michenfelder, M., G. Fu, C. Lawrence, J.C. Weaver, B.A. Wustman, L. Taranto, J.S. Evans and D.E. Morse (2003) Characterization of two molluscan crystal-modulating biomineralization proteins and identification of putative mineral binding domains. Biopolymers 70: 522-533.

Hassenkam, T., G.E. Fantner, J.A. Cutroni, J.C. Weaver, D.E. Morse, and P.K. Hansma (2004) High-resolution AFM imaging of intact and fractured trabecular bone. Bone 35: 4-10. (Cover Article)

Fantner, G.E., H. Birkedal, J.H. Kindt, T. Hassenkam, J.C. Weaver, J.A. Cutroni, B.L. Bosma, L. Bawazer, M.M. Finch, G.A.G. Cidade, D.E. Morse, G. D. Stucky and P.K. Hansma (2004) Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone. Bone 35: 1013-1023. (Cover Article)

Stewart, R.J., J.C. Weaver, D.E. Morse and J. H. Waite (2004) The tube cement of Phragmatopoma californica: a solid foam. J. Exper. Biol. 207: 4727-4734.

Wustman B.A., D.E. Morse and J.S. Evans (2004) Structural characterization of the N-terminal mineral binding domains from the molluscan crystal-modulating biomineralization proteins, AP7 and AP24. Bioploymers 74: 363-376.

Kisailus, D., J.H. Choi, J.C. Weaver, W. Yang and D.E. Morse (2005) Enzymatic synthesis and nanostructural control of gallium oxide at low temperature. Advanced Materials 17: 314-318.

Kim, I.W., D.E. Morse, and J.S. Evans (2004) Molecular characterization of the 30-AA N-terminal mineral interaction domain of the biomineralization protein, AP7. Langmuir 20: 11664-11673.

Roth, K.M., Y. Zhou, W. Yang and D.E. Morse (2005) Bifunctional small molecules are biomimetic catalysts for silica synthesis at neutral pH. J. Amer. Chem. Soc. 127: 325-330.

Kisailus, D., M. Najarian, J.C. Weaver, and D.E. Morse (2005) Functionalized gold nanoparticles mimic catalytic activity of a polysiloxane-synthesizing enzyme. Advanced Materials 17 (10): 1234-1239. (cover article)

Schwenzer B., K.M. Roth, J.R. Gomm, M.M. Murr and D.E. Morse (2005) Kinetically controlled vapor-diffusion synthesis of novel nanostructured metal hydroxide and phosphate films using no organic reagents. Journal of Materials Chemistry: 16: 401-407.

Curnow P., P.H. Bessette, D. Kisailus, M.M. Murr, P.S. Daugherty and D.E. Morse (2005) Enzymatic synthesis of layered titanium phosphates at low temperature and neutral pH by cell-surface display of Silicatein-α. Journal American Chemical Society 127: 15749-15755.

M.M. Murr and D.E. Morse (2005) Fractal intermediates in the self-assembly of Silicatein filaments. Proc. Natl. Acad. Sci. USA 102: 11657-11662.

Fu, G., S. Valiyaveettil, B. Wopenka and D.E. Morse (2005) CaCO3 biomineralization: Acidic 8-kDa proteins isolated from aragonitic abalone shell nacre can specifically modify calcite crystal morphology. Biomacromolecules 6: 1289-1298.

Fu G., S.R Qui, C.A. Orme, D.E. Morse, and J.J. De Yoreo (2005) Acceleration of calcite kinetics by abalone nacre proteins. Advanced Materials 17: 2678-2683. (cover article)

Gotliv, B.A., N. Kessler, J.L. Sumerel, D.E. Morse, N. Tuross, L. Addadi, and S. Weiner (2005) Asprich: a novel aspartic acid-rich protein family from the prismatic shell matrix of the bivalve Atrina rigida. Chem. Biochem. 6: 304-314.

Aizenberg J., J.C. Weaver, M.S. Thanawala, V.C. Sundar, D.E. Morse and P. Fratzl (2005) Skeleton of Euplectella sp.: Structural hierarchy from the nanoscale to the macroscale. Science 309: 275-278. (cover article)

Fantner, G.E., T. Hassenkam, J.S. Kindt, J.C. Weaver, H. Birkedal, L. Pechenik, J.A. Cutroni, G.A.G. Cicade, G.D. Stucky, D.E. Morse, H. Hansma and P.K. Hansma. (2005) Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture. Nature Materials 4: 612-616 (cover article)

Martina M., G. Subramanyam, J.C. Weaver, D.W. Hutmacher, D.E. Morse, and S. Valiyaveettil (2005) Developing macroporous bicontinuous materials as scaffolds for tissue engineering. Biomaterials 26: 5609-5616.

Kisailus D., Y. Amemiya, J.C. Weaver, Q Truong and D.E. Morse (2006) Self-assembled bifunctional surface mimics an enzymatic and templating protein for low-temperature synthesis of a metal oxide semiconductor. Proc. Natl. Acad. Sci. USA 103(15): 5652-5657.

Brutchey, R.L., E.S. Yoo and D.E. Morse (2006) Biocatalytic synthesis of a nanostructured and crystalline bimetallic perovskite-like barium oxofluorotitanate at low temperature. J. Amer. Chem. Soc. 128: 10288-10294.

Brutchey, R.L. and D.E. Morse (2006) Template-free, low-temperature synthesis of crystalline barium titanate nanoparticles under bio-inspired conditions. Angewandte Chemie Intl. Ed 2006, 45: 6564-6566.

Kisailus, D., B. Schwenzer, J. Gomm, J.C. Weaver, and D.E. Morse (2006) Kinetically controlled catalytic formation of zinc oxide thin films at low temperature. J. Amer. Chem. Soc. 128: 10276-10280.

Curnow P., D. Kisailus, and D.E. Morse (2006) Biocatalytic synthesis of poly(L-Lactide) by native and recombinant forms of the Silicatein enzymes. Angewandte Chemie Intl. Ed. 45: 613-616.

Fantner G.E., E. Oroudjev, G. Schitter, L.S. Golde, P. Thurner, M.M. Finch, P. Turner, T. Gutsmann, D.E. Morse, H. Hansma, and P.K. Hansma (2006) Sacrificial bonds and hidden length: Unraveling molecular mesostructures in tough materials. Biophysical Journal 90: 1411-1418.

Thurner, P.J., B. Erickson, Z. Schriock, J. Langan, J. Scott, M. Zhao, J.C. Weaver, G.E. Fantner, P. Turner, J.H. Kindt, G. Schitter, D.E. Morse, P.K. Hansma (2006) High-speed photography of the development of microdamage in trabecular bone during compression. J. Mater. Res. 21(5): 1093-1100.

Fantner G.E., O. Rabinovych, G. Schitter, P. Thurner, J.H. Kindt, M.M. Finch, J.C. Weaver, L.S. Golde, D.E. Morse, E.A. Lipman, I.W. Rangelow, P.K. Hansma (2006) Hierarchical interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales. Composites Science and Technology 66: 1202-1208.

Kim, I.W., S. Collino, D.E. Morse, and J.S Evans (2006) A crystal modulating protein from mulluscan nacre that limits the growth of calcite in vitro. Crystal Growth & Design 6(5): 1078-1082.

Woesz, A., J.C. Weaver, M. Kazanci, Y. Dauphin, J. Aizenberg, D.E. Morse, and P. Fratzl (2006) Micromechanical properties of biological silica in skeletons of deep sea sponges. J. Mater. Res. 21(8): 2068-2078.

Schwenzer, B., J.R. Gomm and D.E. Morse (2006) Substrate-induced growth of nanostructured zinc oxide films at room temperature using concepts of biomimetic catalysis. Langmuir 22: 9829-9831.

Weaver, J.C., J. Aizenberg, G.E. Fantner, D. Kisailus, A. Woesz, P. Allen, K. Fields, M.J. Porter, F.W. Zok, P.K. Hansma, P. Fratzl and D.E. Morse (2006) Hierarchical Assembly of the Siliceous Skeletal Lattice of the Hexactinellid Sponge Euplectella aspergillum. J. Structural Biology 158: 93-106.

Subramanyam, G., L. Rajamani, J. C. Weaver, D.E. Morse, R. Manjunatha Kini, S. Valiyaveettil (2007) In Vitro Study of Magnesium-Calcite Biomineralization in the Skeletal Materials of the Seastar Pisaster giganteus. Chem. Eur. J. 13 (11): 3262 – 3268.

Coral Larvae

Morse, D.E., N. Hooker, A.N.C. Morse and R.A. Jensen (1998) Control of larval metamorphosis and recruitment in sympatric agariciid corals. J. Exper. Mar. Biol. Ecol. 116: 193-217.

Morse, D.E. and A.N.C. Morse (1991) Enzymatic characterization of the morphogen recognized by Agaricia humilis (scleractinian coral) larvae. Biol. Bull. 181: 104-122.

Morse, D.E., A.N.C. Morse, P.T. Raimondi and N. Hooker (1994) Morphogen-based chemical flypaper for Agaricia humilis coral larvae. Biological Bulletin 186: 172-181.

Morse, A.N.C. and D.E. Morse (1996) Flypapers for coral and other planktonic larvae. BioScience 64: 254-262.

Other Signal Molecules, Receptors and Signal Transducers Controlling Larval Metamorphosis

Trapido-Rosenthal, H.G. and D.E. Morse (1986) Availability of chemosensory receptors is down-regulated by habituation of larvae to a morphogenetic signal. Proc. Natl. Acad. Sci. USA 83: 7658-7662.

Baxter, G. and D.E. Morse (1987) G protein and diacylglycerol regulate metamorphosis of planktonic molluscan larvae. Proc. Natl. Acad. Sci. USA 84: 1867-1870.

Morse, D.E. (1990) Recent progress in larval settlement and metamorphosis: Closing the gaps between molecular biology and ecology. Bull. Mar. Sci. 46: 465-483.

Wodicka, L.M. and D.E. Morse (1991) cDNA sequences reveal mRNAs for two Gα signal transducing proteins from larval cilia. Biological Bulletin 180: 318-327.

Baxter, G. and D. E. Morse (1992) Cilia from abalone larvae contain a receptor-dependent G protein transduction system similar to that in mammals. Biological Bulletin 183: 147-154.

Differential Gene Expression Induced at Metamorphosis

Degnan, B.M. and D.E. Morse (1993) Identification of eight homeobox-containing transcripts expressed during larval development and at metamorphsis in the gastropod mollusc Haliotis rufescens. Molecular Marine Biology and Biotechnology 2: 1-9.

Degnan, B.M., S. Degnan, A. Giusti and D.E. Morse (1995) A Hox/Hom homeobox gene in sponges. Gene 155: 175-177.

Degnan, B.M., J.C. Groppe and D.E. Morse (1995) Chymotrypsin mRNA expression in digestive gland amoebocytes: Cell specification occurs prior to metamorphosis and gut morphogenesis in the gastropod, Haliotis rufescens. Roux's Arch. Dev. Biol. 205: 97-101.

Degnan, B.M., S.M. Degnan, and D.E. Morse (1997) Muscle-specific regulation of tropomyosin gene expression and myofibrillogenesis differs among muscle systems examined at metamorphosis of the gastropod Haliotis rufescens. Dev. Genes Evol. 206: 464-471.

Giusti, A.F., V.F. Hinman, S.M. Degnan, B.M. Degnan and D.E. Morse (2000) Expression of a Scr/Hox5 gene in the larval central nervous system of the gastropod Haliotis, a non-segmented spiralian lophotrochozoan. Evolution and Development 2: 294-302.