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His group's research is focused on elucidating structures and interactions of supramolecular assemblies of biological molecules. This includes, understaning structures of DNA condensed by oppositely charged lipids and multivalent counter-ions in vitro and the relationship with condensed DNA in vivo, and developing a fundamental understanding of interactions between cell cytoskeletal proteins and their associated molecules which leads to their distinct structures (related to their specific functions in cells) on the nanometer to the many micrometer scales. A major project in the group has a goal of developing lipid and polymer based non-viral vectors (carriers) of DNA, peptides, and proteins for gene and drug delivery applications. Structures are solved by combining reciprocal space and real space data resulting from x-ray diffraction and scattering, light-microscopy differential-interference-contrast and three-dimensional confocal imaging, and electron microscopy experiments.
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