MCDB Home > Faculty > Thomas Weimbs > Selected Publications

Christiansen JJ, Weimbs T, Bander N, and Rajasekaran AK (2006) Differing effects of microtubule depolymerizing and stabilizing chemotherapeutic agents on t-SNARE-mediated apical targeting of prostate-specific membrane antigen. Mol Cancer Ther 5, 2468-73

Weimbs, T. (2006) Regulation of mTOR by Polycystin-1: is Polycystic Kidney Disease a Case of Futile Repair? Cell Cycle 5, 2425-2429

Kidd GJ, Yadav VK, Huang P, Brand SL, Low SH, Weimbs T, Trapp BD (2006) A dual tyrosine-leucine motif mediates myelin protein P(0) targeting in MDCK cells. Glia 54, 135-145

Sharma N, Low SH, Misra S, Pallavi B, Weimbs T (2006) Apical targeting of syntaxin 3 is essential for epithelial cell polarity The Journal of Cell Biology 173, 937-948

Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T (2006) The mTOR pathway is regulated by polycystin-1 and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proceedings of the National Academy of Sciences of the USA 103, 5466-5471

Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T. (2006) Syntaxins 3 and 4 Are Concentrated in Separate Clusters on the Plasma Membrane before the Establishment of Cell Polarity. Mol Biol Cell. 17(2):977-89.

Low SH, Vasanth S, Larson CH, Mukherjee S, Sharma N, Kinter MT, Kane ME, Obara T, and Weimbs T (2006) Polycystin-1, STAT6 and P100 function in a novel pathway that transduces ciliary mechanosensation to gene expression and is activated in polycystic kidney disease. Developmental Cell 10, 57-69

Fan. S., Hurd, T.W., Liu, C.-J., Straight, S.W., Weimbs, T., Hurd, E.A., Domino, S.E. and Ben Margolis (2004). Polarity proteins control ciliogenesis via kinesin motor interactions. Current Biology 14, 1451-61

Tartakoff A.M., Matera A.G., Pimplikar S.W., Weimbs T. (2004). Regulation of nuclear functions – nucleocytoplasmic transport in context. European Journal of Cell Biology 83, 185-192

Weimbs, T., Low, S.H. and Li, X. (2003) SNAREs and epithelial cells Methods 30, 191-197

Low, S.H., Li, X., Miura, M., Kudo, N., Quinones, B. and Weimbs, T. (2003) Syntaxin 2 and Endobrevin are Required the Terminal Step of Cytokinesis. Developmental Cell 4, 753-759

Kreitzer, G., Schmoranzer, J., Low, S.H., Li, X., Gan, Y., Weimbs, T., Simon, S.M. and Rodriguez-Boulan, E. (2003) Three-dimensional Analysis of Post-Golgi Carrier Exocytosis in Epithelial Cells. Nature Cell Biology 5, 126-136

Sherief, M.H., Low, S.H., Miura, M., Kudo, N., Novick, A.C. and Weimbs, T. (2003) Matrix Metalloproteinase Activity in Urine of Renal Cell Carcinoma Patients Leads to Degradation of Extracellular Matrix Proteins: Possible Use as a Screening Assay. Journal of Urology 169, 1530–1534

Low, S.H., Marmorstein, L.Y, Miura, M., Li, X., Kudo, N., Marmorstein, A.D. and Weimbs, T. (2002) Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype. Journal of Cell Science 115, 4545-4553

Li, X., Low, S.H., Miura, M. and Weimbs, T. (2002) Differential SNARE Expression and Localization in Renal Epithelial Cells suggests mechanism for establishment of distinct trafficking phenotypes. American Journal of Physiology 283: F1111–F1122

van IJzendoorn SC, Tuvim MJ, Weimbs T, Dickey BF, Mostov KE. (2002). Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. Developmental Cell 2, 219-28

Lim, S. N., Bonzelius, F., Low, S. H., Wille, H., Weimbs, T., and Herman, G. A. (2001). Identification of discrete classes of endosome-derived small vesicles as a major cellular pool for recycling membrane proteins. Molecular Biology of the Cell 12, 981-95

Low, S. H., Miura, M., Roche, P. A., Valdez, A. C., Mostov, K. E., and Weimbs, T. (2000)
Intracellular re-direction of plasma membrane trafficking after loss of epithelial cell polarity.
Molecular Biology of the Cell 11, 3045-3060

S. H. Low, S. J. Chapin, C. Wimmer, S. W. Whiteheart, L. K. Kömüves, K. E. Mostov, and T. Weimbs (1998). The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. Journal of Cell Biology 141, 1503-1513

T. Weimbs, K. E. Mostov, S. H. Low and K. Hofmann (1998) A model for structural similarity between different SNARE complexes based on sequence relationships Trends in Cell Biology 8, 260-262

S. H. Low, P. A. Roche, H. A. Anderson, S. C. D. van IJzendoorn, M. Zhang, K. E. Mostov, and T. Weimbs, (1998). Targeting of SNAP-23 and SNAP-25 in Polarized Epithelial Cells Journal of Biological Chemistry 273, 3422-3430

T. Weimbs, S. H. Low, S. J. Chapin, and K. E. Mostov (1997)Apical targeting in polarized epithelial cells: there's more afloat than rafts Trends in Cell Biology 7, 393-399

T. Weimbs, S. H. Low, S. J. Chapin, K. E. Mostov, P. Bucher and K. Hofmann (1997) A conserved domain is present in different families of vesicular fusion proteins: A new superfamily Proc. Natl. Acad. Sci. USA 94, 3046-3051

S. H. Low*, S. J. Chapin*, T. Weimbs*, L. G. Kömüves, M. K. Bennett and K. E. Mostov (1996) Differential Localization of Syntaxin Isoforms in Polarized MDCK Cells Molecular Biology of the Cell 7, 2007-2018
(*equal first authorship)

K. E. Mostov, Y. Altschuler, S. J. Chapin, C. Enrich, S. H. Low, F. Luton, J. Richman- Eisenstat, K. L. Singer, K. Tang and T. Weimbs (1995) Regulation of Protein Traffic in Polarized Epithelial Cells: The Polymeric Immunoglobulin Receptor Model Cold Spring Harb. Symp. Quant. Biol. 60, 775-781

T. Weimbs and W. Stoffel (1994) Topology of CNS myelin proteolipid protein: evidence for the nonenzymatic glycosylation of extracytoplasmic domains in normal and diabetic animals Biochemistry 33, 10408-15

T. Weimbs and W. Stoffel (1992) Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid thioester-linked cysteine residues and implications for the membrane topology of PLP Biochemistry 31, 12289-96

T. Weimbs, T. Dick, W. Stoffel and E. Boltshauser (1990) A point mutation at the X-chromosomal proteolipid protein locus in Pelizaeus-Merzbacher disease leads to disruption of myelinogenesis Biological Chemistry Hoppe Seyler 371, 1175-83