MCDB Home > Faculty > Leslie Wilson > Selected Publications

Skoufias, D.A., Lacroix, F.B., Andreassen, P.R., Wilson, L. and Margolis. R.L. Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase. Molec. Cell 15, 977-990. 2004

Honore, S., Kamath, K., Braguer, D., Horwitz, S.B., Wilson, L., Briand, C., and Jordan, M.A. Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer Res. 64, 4957-4964, 2004

Newton, C. N., Wagenbach, M., Ovechkina, Y., Wordeman, L., and Wilson, L. MCAK, a kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro. FEBS Lett. 572, 80-84, 2004.

Jordan, M.A., and Wilson, L. (2004) Microtubules as a target for anticancer drugs. Nature Cancer Reviews. 4: 253-265.

Bunker, JM., Wilson, L, Jordan, MA, Feinstein, SC. Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegeneration. Mol. Biol. Cell 15, 2720-2728, 2004.

Needleman, D., Ojeda-Lopez, M. A., Raviv, U., Ewert, K., Jones, J. B., Miller, H. P., Wilson, L., and Safinya, C. R. Synchrotron X-ray diffraction study of microtubules buckling and bundling under osmotic stress: A probe of inter-protofilament interactions. Phys. Rev. Lett 9, 198104-1, 2004.

Kamath, K., Wilson, L., Cabral, F., and Jordan, M.A. III-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability. J. Biol. Chem. 280, 12902-12907, 2005.

Levy, S.F., LeBouef, A.C., Massie, M.R., Jordan, M.A., Wilson, L., and Feinstein, S.C. Three and four-repeat tau regulate the dynamic instability of two distinct microtubule subpopulations in quantitatively different manners: implications for neurodegeneration J. Biol. Chem. 280, 13520-13528, 2005.

Panda, D., Rathinasamy, K., Manas, S.K., and Wilson, L. Kinetic suppression of microtubule dynamic instability by griseofulvin: Implications for its possible use in the treatment of cancer. Proc. Natl. Acad. Sci (USA) 102, 9878-9883, 2005.

Raviv, U., Needleman, D.J., Li, Y., Miller, H.P., Wilson, L., and Safinya, C.R. Cationic liposome-microtubule complexes: Pathways to the formation of two-state lipid-protein nanotubes with open or closed ends. Proc. Natl. Acad. Sci (USA) 102, 11167-11172, 2005.

Jordan, MA, Kamath, K, Manna, T, Okouneva, T, Miller, HP, Davis, C, Littlefield, BA, Wilson, L. The primary mechanism of action of the synthetic halichondrins, E7389, is suppression of microtubule growth. Molec. Cancer Ther 4, 1086-1095, 2005.

Needleman, D.J., Jones, J. B., Raviv, U., Ojeda-Lopez, M.A., Miller, H.P., Wilson, L., and Safinya, C.R. Supramolecular assembly of biological molecules purified from bovine nerve cells: from microtubule bundles and necklaces to neurofilament networks. J. Phys.:Cond.Matt. 17:S3225-S3230, 2005.

Needleman, D.J., Ojeda-Lopez, M.A., Raviv, U., Ewert, K., Miller, H.P., Wilson, L., and Safinya, C.R. Radial Compression of Microtubules and the Mechanism of Action of Taxol and Associated Proteins. Biophys J. 89, 3410-3423, 2005.

Bunker, J.M., Kamath, K., Wilson, L., Jordan, M.A., Feinstein, S.C. FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells. J. Biol. Chem. 281, 11856-11863, 2006.

Manna, T., Thrower, D. Miller, H.P., Curmi, P, Wilson, L. Stathmin strongly increases the minus end catastrophe frequency and induces rapid treadmilling of bovine brain microtubules at steady state In vitro. J. Biol. Chem. 281, 2071-2078, 2006.

Mohan, R., Banerjee, M., Ray, A., Manna, T., Wilson, L., Owa, T., Bhattacharyya, B., and Panda, D. Antimitotic sulfonamides inhibit microtubule assembly dynamics and cancer cell proliferation. Biochemistry, 45, 5440-5449, 2006.

Kamath, K., Okouneva, T., Larson, G., Panda, D., Wilson, L., Jordan, M.A. 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Mol. Cancer Ther. 5, 2225-33, 2006.

Raviv, U., Nguyen, T., Ghafouri, R., Needleman, D.J., Li, Y., Miller, H.P., Wilson, L., Bruinsma, R.F., and Safinya, C.R. Microtubule protofilament number is modulated in a step wise fashion by the charge density of an enveloping layer. Biophys. J. 92, 278-287, 2007.

Manna, T., Grenningloh, G, Miller, H.P., Wilson, L. Stathmin family protein SCG10 differentially regulates plus and minus end dynamics of microtubules at steady state in vitro: implications for its role in neurite outgrowth. Biochemistry (In Press) March, 2007.

Ray, A., Okouneva, T., Manna, T., Miller, H.P., Schmid, S., Arthaud, L., Jordan, M.A., Wilson, L. Mechanism of action of the microtubule-targeted antimitotic depsipeptide tasidotin (formerly ILX651) and its major metabolite, tasidotin-C-carboxylate. Cancer Res. (In Press) 2007.