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Thales P. Papagiannakopoulos
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Education:
2001-2004, BSc, Molecular Genetics, University of Sussex, UK
2004-2005, Research Asssistant, Department of Cell Biology, The Scripps Research Institute, La Jolla
2005-current, Ph.D. candidate, Department of Molecular, Cellular and Developmental Biology
Research Interests:
With over 460 miRNA genes identified experimentally in the human genome and a plethora of computatiaonally predicted mRNA targets, it is believed that these small RNAs have a central role in diverse cellular and developmental processes. Therefore aberrant expression of miRNA genes could lead to human disease, including cancer. There are several recent studies that have confirmed that miRNAs regulate cell proliferation and apoptosis.
miRNAs are playing an important role in inducing and maintaining the oncogenic state of various types of cancer. This function lies within their ability to target multiple transcripts including many tumor suppressor genes or oncogenes.
E-mail: papagian at lifesci.ucsb.edu
Publications:
Deryugina EI, Zijlstra A, Partridge JJ, Kupriyanova TA, Madsen MA, Papagiannakopoulos T, Quigley JP. Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. Cancer Res. 2005 Dec 1;65(23):10959-69.
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