|
Education:
2001-2004, BSc, Molecular Genetics, University of Sussex, UK
2004-2005, Research Asssistant, Department of Cell Biology, The Scripps Research Institute, La Jolla
2005-current, Ph.D. candidate, Department of Molecular, Cellular and Developmental Biology, UC Santa Barbara
Research Interests:
With over 600 miRNA genes identified experimentally in the human genome and a plethora of computatiaonally predicted mRNA targets, it is believed that these small RNAs have a central role in diverse cellular and developmental processes. Therefore aberrant expression of miRNA genes could lead to human disease, including cancer. Studies from our group and other have confirmed that miRNAs regulate cell proliferation and apoptosis. Furthermore, these non-coding RNAs can control cellular identity and mediate differentiation.
miRNAs are playing an important role in inducing and maintaining the oncogenic state of various types of cancer. This function lies within their ability to target multiple transcripts including many tumor suppressor genes or oncogenes.
With the use of gliomas as a model, we aim to determined the role of miRNAs in epigenetically regulating oncogenesis and tumor maintenance.
E-mail: papagian at lifesci.ucsb.edu
Publications:
- Papagiannakopoulos T, Kosik KS. MicroRNA-124: Micromanager of Neurogenesis. Cell Stem Cell, 2009 May 8;4(5):375-76
- Xu
N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS. MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells. CELL. 2009 May 15;137
- Carrettiero
DC, Hernandez I, Neveu P, Papagiannakopoulos T, Kosik KS. The
cochaperone BAG2 sweeps paired helical filament- insoluble tau from the
microtubule. J Neurosci. 2009 Feb 18;29(7):2151-61
- Papagiannakopoulos T, Shapiro A, Kosik KS.
MicroRNA-21 targets a network of key tumor-suppressive pathways in
glioblastoma cells. Cancer Res. 2008 Oct 1;68(19):8164-72
- Papagiannakopoulos T, Kosik KS. microRNAs: regulators of
oncogenesis and stemnes. BMC Med. 2008 Jun 24;6(1):15.
- Liu T,
Papagiannakopoulos T, Puskar K, Qi S, Santiago F, Clay W, Lao K, Lee Y,
Nelson SF, Kornblum HI, Doyle F, Petzold L, Shraiman B, Kosik KS. Detection of a MicroRNA Signal in an In Vivo Expression Set of mRNAs. PLoS ONE. 2007 Aug 29;2(8):e804.
|
