The Rothman Lab NEUROSCIENCE RESEARCH INSTITUTE and DEPARTMENT OF MOLECULAR, CELLULAR and DEVELOPMENTAL BIOLOGY UC SANTA BARBARA, SANTA BARBARA, CA 93106 |
Research Projects
1. Elucidate a novel left-right handedness choice mechanism in sensory neurons of the nematode C. elegans.
2. Find a cleavage site in anti-apoptotic ICD-1 protein cleaved by CED-3, caspase protein in C. elegans.
3. Test toxicity of nanoparticles in multicellular organisms and apply nanomaterials to gene therapy.
Honors and Awards
Grandprix at the Korean Society for Biotechnology and Bioengineering (2004).
Outstanding Ph. D. Student Scholarship by Korea Research Foundation (2004-2005).
Postdoctoral Fellowship by Korea Research Foundation (2006).
Travel Award by Genetic Society of America (2008).
Publications
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Oh JS, Choi SS, Yeo JK, Park TH. (2007) Construction of various bacteriophage 1 mutantas for stable and efficient production of recombinant protein in Escherichia coli. Process Biochem. 42, 486-490. Abstract
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Park JG, Choi SS, Park TH. (2007) Enhancement of cell growth and viability of CHO cells in serum-free media by 30Kc6 gene expression. Process Biochem. 42, 8-15. Abstract
- Choi SS and Park TH. (2006) Enhancement of sialyltransferase-catalyzed transfer of sialic acid onto glycoprotein oligosaccharides using silkworm hemolymph and its 30K protein. Journal of Mol. Cat.B:Enzymatic. 43, 128-132. Abstract
- Choi SS, Rhee WJ, Kim EJ, Park TH. (2006) Enhancement of recombinant protein production in Chinese hamster ovary cells through anti-apoptosis engineering using 30Kc6 gene. Biotechnol. Bioeng. 95: 459-467. Abstract
- Choi SS, Rhee WJ, Park TH. (2002) Inhibition of human cell apoptosis by silkworm hemolymph. Biotechnol. Prog. 18:874-878. Abstract
Patents
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Tai Hyun Park, Eun Jeong Kim, Won Jong Rhee, and Shin Sik Choi, “Methods for separation and purification of functional fractions from silkworm hemolymph that inhibits apoptosis in mammalian cells” Korea Patent 10-0530506 (2005).
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Tai Hyun Park and Shin Sik Choi, “Chinese hamster ovary cell line transfected with 30K gene” Korea Patent 10-2006-0031751 (2006).
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Tai Hyun Park and Shin Sik Choi, “Chinese hamster ovary cell line transfected with 30K gene” US Patent 10/963,770 (2006).
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Tai Hyun Park, Shin Sik Choi, and Hong Jae Lee, “Method for homing and attaching cells to a target site using magnetic nanoparticles” Korea Patent 10-07921858 (2007).
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Tai Hyun Park, Shin Sik Choi, and Joo Hyun Park, “Method for improving glycosylation pattern in recombinant protein” Korea Patent 10-2008-0035777 (2008).