The Rothman Lab NEUROSCIENCE RESEARCH INSTITUTE and DEPARTMENT OF MOLECULAR, CELLULAR and DEVELOPMENTAL BIOLOGY UC SANTA BARBARA, SANTA BARBARA, CA 93106

Shin Sik Choi Postdoc shinsik@gmail.com

Research Projects

1. Elucidate a novel left-right handedness choice mechanism in sensory neurons of the nematode C. elegans.

2. Find a cleavage site in anti-apoptotic ICD-1 protein cleaved by CED-3, caspase protein in C. elegans.

3. Test toxicity of nanoparticles in multicellular organisms and apply nanomaterials to gene therapy.

Honors and Awards

Grandprix at the Korean Society for Biotechnology and Bioengineering (2004).

Outstanding Ph. D. Student Scholarship by Korea Research Foundation (2004-2005).

Postdoctoral Fellowship by Korea Research Foundation (2006).

Travel Award by Genetic Society of America (2008).

Publications

• Oh JS, Choi SS, Yeo JK, Park TH. (2007) Construction of various bacteriophage 1 mutantas for stable and efficient production of recombinant protein in Escherichia coli. Process Biochem. 42, 486-490. Abstract

• Park JG, Choi SS, Park TH. (2007) Enhancement of cell growth and viability of CHO cells in serum-free media by 30Kc6 gene expression. Process Biochem. 42, 8-15. Abstract

• Choi SS and Park TH. (2006) Enhancement of sialyltransferase-catalyzed transfer of sialic acid onto glycoprotein oligosaccharides using silkworm hemolymph and its 30K protein. Journal of Mol. Cat.B:Enzymatic. 43, 128-132. Abstract

• Choi SS, Rhee WJ, Kim EJ, Park TH. (2006) Enhancement of recombinant protein production in Chinese hamster ovary cells through anti-apoptosis engineering using 30Kc6 gene. Biotechnol. Bioeng. 95: 459-467. Abstract

• Choi SS, Rhee WJ, Park TH. (2005) Beneficial effect of silkworm hemolymph on CHO cell system: Inhibition of apoptosis and increase of EPO production. Biotechnol. Bioeng. 91:793-800.   Abstract