Area of general research interest:

Function of polycystin-1, the polycystic kidney disease gene product.

Professional education and positions held:

2005-present	Project Scientist, Department of Molecular, Cellular, and Developmental Bioloogy, UCSB
2003-2005	Research Associate, Department of Cell Biology, The Cleveland Clinic, OH
1998-2003	Postdoctoral Research Fellow, National Institute of Diabetes and Digestive and Kidney Disorders, National Institutes of Health, Bethesda, MD
1994-1998	Postgraduate, Hannah Research Institute, Scotland/University of Wales, Aberystwyth, UK
1994-1998	Undergraduate student, University of Wolverhampton, UK

Awards and Fellowships

• Congressionally Directed Medical Research Program, Department of Defense - Breast Cancer Research Program award (Aug 2001 - Aug 2003)
• Scientist Development Grant, American Heart Association (2006-2010)

Memberships in professional societies

Science Advisory Board member
Grant reviewer, Biotechnology and Biological Sciences Research Council

Publications

Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T (2006)
The mTOR pathway is regulated by polycystin-1 and its inhibition reverses renal cystogenesis in polycystic kidney disease.
Proceedings of the National Academy of Sciences of the USA 103, 5466-5471

Cases, S., Zhou, P., Shillingford, J.M., Wiseman, B.S., Fish, J.D., Angle, C.S., Hennighausen, L., Werb, Z. and Farese, Jr., R.V. (2004). Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development. Accepted.

Long, W., Wagner, K.U., Lloyd, K.C.K., Binart, N., Shillingford, J.M., Hennighausen, L. and Jones, F. (2003). Conditional deletion of Erbb4 in the mammary gland identifies ErbB4 as an obligate mediator of Stat5 activation and epithelial functional differentiation. Development, 130, 5257-5268.

Bierie, B., Nozawa, M., Renou, J.-P., Shillingford, J.M., Morgan, F., Oka, T., Taketo, M.M., Cardiff, R.D., Miyoshi, K., Wagner, K-U., Robinson, G.W. and Hennighausen, L. (2003). Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. Oncogene 22:3875-3877.

Shillingford, J.M., Miyoshi, K., Robinson, G.W., Bierie, B., Cao, Y., Karin, M. and Hennighausen, L.(2003). Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers. A tool to define developmental lesions. J. Histochem. Cytochem. 51:555-565.

Shillingford, J.M., Miyoshi, K., Flagella, M., Shull, G.E. and Hennighausen, L. (2002). Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. Mol. Endocrinol. 16:1309-1321.

Shillingford, J.M., Miyoshi, K., Robinson, G.W., Grimm, S.L., Rosen, J.M., Neubauer, H., Pfeffer, K. and Hennighausen, L. (2002). Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium. Mol. Endocrinol. 16:563-570.

Miyoshi, K., Shillingford, J.M., Le Provost, F., Gounari, F., Bronson, R., von Boehmer, H., Taketo, M.M., Cardiff, R.D., Hennighausen, L. and Khazaie, K. (2002). Activation of beta-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias. Proc. Natl. Acad. Sci. 99:219-224.

Walton, K.D., Wagner, K.U., Rucker, E.B. 3rd, Shillingford, J.M., Miyoshi, K. and Hennighausen, L. (2001). Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation. Mech. Dev. 109:281-293.

Miyoshi, K., Shillingford, J.M., Smith, G.H., Grimm, S.L., Wagner, K.U., Oka, T., Rosen, J.M., Robinson, G.W. and Hennighausen, L. (2001). Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J. Cell. Biol. 155:531-542.

Shillingford, J.M. and Hennighausen, L. (2001). Experimental mouse genetics -- answering fundamental questions about mammary gland biology. Trends Endocrinol. Metab. 12:402-408. Review.