Alignment of the conserved domains of representative members of the SNARE subfamilies. The cytoplasmic regions with a high likelihood of coiled-coil structure is highlighted together with the register of the heptad repeat. All subfamilies, except the SNAP-25 family, possess a C-terminal transmembrane domain which is separated from the coiled-coil domain by a cluster of basic amino acids (cyan). The conserved glutamine and arginine residues in a 'd'-position of the heptad repeat are indicated in red and green, respectively. Species abbreviations are as in figure 1. Stx = syntaxin. TSL = t-SNARE like protein*. Two-letter species abbreviations after the protein name: RN, rattus norvegicus; HS, homo sapiens; CE, caenorhabditis elegans; SC, saccharomyces cerevisiae; AT, arabidopsis thaliana; MM, mus musculus; CG, cricetulus griseus. NT and CT refers to the N-terminal and C-terminal coiled-coil domain of SNAP-25-related proteins, respectively.

*see the following reference: Weimbs, T., Low, S. H., Chapin, S. J., Mostov, K. E., Bucher, P., and Hofmann, K. (1997). A conserved domain is present in different families of vesicular fusion proteins: A new superfamily. Proc. Natl. Acad. Sci. USA 94, 3046-3051

Download a printable MS-Word version: click here

For questions/comments etc. contact Thomas Weimbs at weimbs@lifesci.ucsb.edu